Back to Nephrology
10 marksDrNB 2025NephrologyDiabetic Kidney Disease
a) Discuss briefly role of inflammation, immunity, oxidative stress and fibrosis in pathogenesis of diabetic kidney disease. [7] b) Discuss potential role of JAK (Janus kinase) inhibitors in kidney disorders. [3]
JAK (Janus kinase) inhibitors are small molecule drugs that block JAK-STAT signalling pathways involved in cytokine receptor-mediated immune and inflammatory responses (Firestein's Rheumatology, 11e).
JAK enzymes transduce signals from multiple cytokines (IL-6, IFN-γ), contributing to inflammation and fibrosis in renal diseases such as autoimmune nephritis, DKD, and glomerulonephritis.
References
Brenner & RectorBrenner & Rector's The Kidney, 11eFirestein's Rheumatology, 11eHarrison's 21eHarrison's 21e, Ch. 348Robbins & Cotran, 10e